Charles Brenner Selected Research

diadenosine polyphosphate hydrolase

2/2003	Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding.
1/2001	Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the alpha-beta bridging oxygen and beta phosphorus replacement.

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Charles Brenner Research Topics

Disease

12	Neoplasms (Cancer) 01/2019 - 01/2001
5	Insulin Resistance 01/2021 - 01/2016
4	Inflammation (Inflammations) 06/2021 - 01/2018
3	Weight Loss (Weight Reduction) 01/2020 - 01/2019
3	Peripheral Nervous System Diseases (PNS Diseases) 10/2018 - 01/2016
3	Type 2 Diabetes Mellitus (MODY) 01/2018 - 01/2016
3	Hypersensitivity (Allergy) 01/2017 - 03/2002
2	Neurodegenerative Diseases (Neurodegenerative Disease) 06/2021 - 10/2016
2	Demyelinating Diseases (Demyelinating Disease) 01/2021 - 10/2020
2	Neuroinflammatory Diseases 01/2021 - 10/2020
2	Coronavirus Infections 12/2020 - 10/2020
2	COVID-19 12/2020 - 10/2020
2	Mitochondrial Myopathies (Mitochondrial Myopathy) 07/2020 - 01/2020
2	Metabolic Diseases (Metabolic Disease) 01/2020 - 10/2016
2	Glioma (Gliomas) 01/2019 - 08/2003
2	Prediabetic State (Prediabetes) 01/2018 - 01/2016
2	Weight Gain 01/2016 - 08/2015
2	Breast Neoplasms (Breast Cancer) 08/2013 - 08/2006
2	Infections 01/2008 - 01/2007
2	Early-onset ataxia with oculomotor apraxia and hypoalbuminemia 11/2004 - 07/2002
1	Ocular Hypertension (Glaucoma, Suspect) 06/2021
1	Glaucoma 06/2021
1	Liver Diseases (Liver Disease) 08/2020
1	Sepsis (Septicemia) 01/2020
1	Circadian Rhythm Sleep Disorders (Delayed Sleep Phase Syndrome) 01/2020
1	Fatigue 01/2020
1	Parkinson Disease (Parkinson's Disease) 01/2020
1	Retinal Degeneration 01/2020
1	Retinal Diseases 01/2020
1	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2020
1	Autism Spectrum Disorder 01/2020
1	Overweight 01/2019
1	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2018
1	Heart Failure 01/2018
1	Cardiomegaly (Heart Hypertrophy) 01/2018
1	Flushing 01/2018
1	Obesity 01/2018
1	Lung Neoplasms (Lung Cancer) 09/2017
1	Hyperglycemia 01/2016
1	Diabetic Neuropathies (Diabetic Neuropathy) 01/2016
1	Carcinogenesis 01/2014
1	Leukemia 11/2013

Drug/Important Bio-Agent (IBA)

18	NAD (NADH)IBA 06/2021 - 01/2007
17	nicotinamide-beta-ribosideIBA 06/2021 - 05/2004
11	EnzymesIBA 12/2020 - 01/2001
5	Niacinamide (Nicotinamide)FDA LinkGeneric 12/2020 - 01/2008
4	Niacin (Nicotinic Acid)FDA LinkGeneric 07/2020 - 01/2008
4	Glucose (Dextrose)FDA LinkGeneric 01/2018 - 01/2016
4	DNA (Deoxyribonucleic Acid)IBA 01/2014 - 11/2004
4	HydrolasesIBA 02/2003 - 01/2001
3	Proteins (Proteins, Gene)FDA Link 10/2018 - 11/2004
3	MethyltransferasesIBA 01/2014 - 01/2013
2	Retinaldehyde (Retinal)IBA 06/2021 - 01/2020
2	Nicotinamide MononucleotideIBA 01/2021 - 10/2016
2	Coenzymes (Enzyme Cofactors)IBA 01/2020 - 01/2018
2	Nicotinamide PhosphoribosyltransferaseIBA 01/2019 - 11/2013
2	Biomarkers (Surrogate Marker)IBA 01/2018 - 09/2017
2	LipidsIBA 01/2018 - 08/2015
2	Histidine (L-Histidine)FDA Link 01/2014 - 02/2003
2	Decitabine FDA Link 08/2013 - 01/2013
2	Pharmaceutical PreparationsIBA 08/2013 - 05/2004
2	Phosphotransferases (Kinase)IBA 05/2004 - 03/2002
2	diadenosine polyphosphate hydrolaseIBA 02/2003 - 01/2001
1	Glial Fibrillary Acidic ProteinIBA 06/2021
1	LipopolysaccharidesIBA 01/2021
1	CuprizoneIBA 01/2021
1	NucleotidesIBA 01/2020
1	Oxytocin (Pitocin)FDA LinkGeneric 01/2020
1	ChromatinIBA 01/2020
1	Fatty Acids (Saturated Fatty Acids)IBA 04/2019
1	CarbohydratesIBA 04/2019
1	ProlactinIBA 01/2019
1	dipinacoline glutamateIBA 01/2019
1	ChloridesIBA 01/2019
1	Phosphoprotein Phosphatases (Phosphatases, Protein)IBA 01/2019
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2019
1	Phosphates (Orthophosphate)IBA 01/2018
1	Serum Response FactorIBA 01/2018
1	Insulin (Novolin)FDA Link 01/2018
1	PalmitatesIBA 01/2018
1	PentosesIBA 01/2018
1	Capsules (Microcapsules)IBA 01/2018
1	Transcription Factors (Transcription Factor)IBA 01/2018
1	GlycogenIBA 01/2018
1	mouse MIRN29 microRNAIBA 09/2017
1	Acetylcarnitine (Alcar)IBA 01/2017
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2017
1	Streptozocin (Streptozotocin)FDA Link 01/2016
1	NADP (NADPH)IBA 01/2016
1	Blood Glucose (Blood Sugar)IBA 01/2016
1	N-nitroso-N-methyltyramine (NNMT)IBA 08/2015
1	Sirtuin 1IBA 08/2015
1	CarcinogensIBA 01/2014

Therapy/Procedure

2	Therapeutics 01/2019 - 01/2018
2	Drug Therapy (Chemotherapy) 10/2018 - 01/2017
1	Intracameral Injection 06/2021
1	Microspheres (Microsphere) 06/2021
1	Axotomy 10/2020
1	Liver Transplantation 08/2020
1	Oral Administration 01/2017